Tetrahydropyranyl derivatives of daunomycin and adriamycin.
نویسندگان
چکیده
منابع مشابه
Comparative Pharmacokinetics of Daunomycin and Adriamycin in Several Animal Species1
The physiological disposition of adriamycin and daunomycin has been studied in several animal species. Both drugs were rapidly cleared from plasma, deposited in tissues, and then excreted slowly. Drug and metabolites were excreted via the bile and urine. Daunomycin was extensively metabolized by mice, rats, dogs, and hamsters, whereas no evidence was obtained for the metabolism of adriamycin in...
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It has been shown that the antitumor antibiotics daunomycin (1) and adriamycin (4) are metabolized by microorganisms in a fashion similar to their metabolism by mammalian cells. Both the fungus Mucor spinosus and its cell-free extracts reduce the 13-keto group of daunomycin to give daunomycinol (2) by a TPNH-dependent process. Cell-free extracts of Streptomyces steffisburgensis convert adriamyc...
متن کاملStructural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
The anticancer drugs adriamycin and daunomycin have each been crystallized with the DNA sequence d(CGATCG) and the three-dimensional structures of the complexes solved at 1.7- and 1.5-A resolution, respectively. These antitumor drugs have significantly different clinical properties, yet they differ chemically by only the additional hydroxyl at C14 of adriamycin. In these complexes the chromopho...
متن کاملComparative Biochemical Studies of Adriamycin and Daunomycin in Leukemic Cells1
Adriamycin (AM) and daunomycin (DM) were compared as inhibitors of nucleic acid and protein biosynthesis in LI 210 leukemic cells. In vivo, both antibiotics markedly inhibited, without significant difference, the incorporation of the labeled precursors into DNA and RNA. In vitro, at a concentration of 5 or lOjUg/ml, DM was significantly more effective than AM in inhibiting DNA and RNA synthesis...
متن کاملComparative pharmacokinetics of daunomycin and adriamycin in several animal species.
The physiological disposition of adriamycin and daunomycin has been studied in several animal species. Both drugs were rapidly cleared from plasma, deposited in tissues, and then excreted slowly. Drug and metabolites were excreted via the bile and urine. Daunomycin was extensively metabolized by mice, rats, dogs, and hamsters, whereas no evidence was obtained for the metabolism of adriamycin in...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1979
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.32.1082